Population
Single canine ventricular myocytes with induced early afterdepolarizations, delayed afterdepolarizations…
Comparison
Pinacidil and protein kinase C activator 4… vs Control conditions
Design
Preclinical
Authors
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Supports K+ channel activation for suppressing triggered activity in myocytes; leaves open translation to in vivo models or patients.
Augmentation of repolarizing outward potassium currents using pinacidil effectively suppresses abnormal impulse generation in ventricular myocytes, highlighting a potential novel antiarrhythmic mechanism.
Spinelli et al. (1991) studied this question.
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