Pinacidil-induced electrical heterogeneity and extrasystolic activity in canine ventricular tissues. Does activation of ATP-regulated potassium current promote phase 2 reentry?
Key result
Pinacidil (1 to 5 mumol/L) induced extrasystolic activity displaying features of reentry in 63.2% of isolated canine ventricular epicardium sheets, compared to 0% in its absence.
Why the study?
Does pinacidil-induced activation of ATP-regulated potassium current promote phase 2 reentry and extrasystolic activity in canine ventricular tissues?
Population
Isolated canine ventricular epicardium and endocardium tissues
Comparison
Pinacidil (1 to 5 mumol/L) vs Absence of pinacidil
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications; hypothesis-generating for IK-ATP activation in phase 2 reentry.
Structured PICO
Does pinacidil-induced activation of ATP-regulated potassium current promote phase 2 reentry and extrasystolic activity in canine ventricular tissues?
P
Population
Isolated canine ventricular epicardium and endocardium tissues
I
Intervention
Pinacidil (1 to 5 mumol/L)
C
Comparator
Absence of pinacidil
O
Outcome
Electrophysiological changes including dispersion of repolarization, refractoriness, action potential duration (APD90), and extrasystolic activitysurrogate
Main Result
Absolute Event Rate: 63.2% vs 0%
Activation of ATP-regulated potassium channels by pinacidil produces marked dispersion of repolarization and refractoriness in canine ventricular epicardium, promoting extrasystolic activity via phase 2 reentry.
Cite This Study
Diego et al. (1993) studied Arrhythmogenesis and electrical heterogeneity. Pinacidil vs. Absence of pinacidil was evaluated on Extrasystolic activity displaying features of reentry in isolated sheets of epicardium. Pinacidil (1 to 5 mumol/L) induced extrasystolic activity displaying features of reentry in 63.2% of isolated canine ventricular epicardium sheets, compared to 0% in its absence.