Key result
Pinacidil administration in dogs with 4-day-old healing infarcts restored conduction and excitability in initially inexcitable epicardial border zones (6 of 8 experiments), causing tachycardia.
Why the study?
Does pinacidil alter electrophysiological properties and arrhythmogenesis in the epicardial border zone of healing canine infarcts?
Population
Dogs with 4-day-old healing myocardial infarction produced by ligation of the left anterior descending…
Comparison
Pinacidil administered directly into the… vs Baseline
Design
Preclinical
Authors
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May promote arrhythmias in healing infarcts; leaves open net KATP effects on human post-MI arrhythmogenesis.
Does pinacidil alter electrophysiological properties and arrhythmogenesis in the epicardial border zone of healing canine infarcts?
K ATP channels in the epicardial border zone of healing infarcts remain functional and their activation alters electrophysiological properties, which can either promote or prevent arrhythmogenesis depending on baseline tissue excitability.
Coromilas et al. (2002) studied Myocardial infarction. Pinacidil was evaluated on Impulse propagation, conduction, excitability, and arrhythmogenesis in the epicardial border zone. Pinacidil administration in dogs with 4-day-old healing infarcts restored conduction and excitability in initially inexcitable epicardial border zones (6 of 8 experiments), causing tachycardia.
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