Key result
In isolated rabbit hearts, pinacidil infusion shortened action potential duration (105 ± 10 msec) but not the QT interval (199 ± 14 msec), which correlated with intracellular calcium transient duration.
Why the study?
Does pinacidil infusion alter action potential duration and QT interval in isolated rabbit hearts?
Population
15 isolated rabbit hearts
Comparison
Pinacidil infusion (80 microM) vs Baseline (prior to pinacidil infusion)
Design
Preclinical
Authors
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No immediate clinical implications from isolated rabbit hearts; leaves open KATP effects on repolarization heterogeneity for in vivo validation.
Does pinacidil infusion alter action potential duration and QT interval in isolated rabbit hearts?
p-value: p=<0.05
K(ATP) channel opening with pinacidil shortens action potential duration but not the QT interval, likely due to prolonged intracellular calcium transients creating heterogeneous membrane potential distribution.
Wu et al. (2005) studied Acute myocardial ischemia (n=15). Pinacidil vs. Baseline was evaluated on Action potential duration (APD90), QT interval, and duration of intracellular calcium transient (DCaT90) (p=<0.05). In isolated rabbit hearts, pinacidil infusion shortened action potential duration (105 ± 10 msec) but not the QT interval (199 ± 14 msec), which correlated with intracellular calcium transient duration.
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