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October 1, 1993CirculationOpen Access

Role of ATP-sensitive K+ channel on ECG ST segment elevation during a bout of myocardial ischemia. A study on epicardial mapping in dogs.

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Why the study?

Does the activation of ATP-sensitive K+ channels contribute to ECG ST segment elevation during acute myocardial ischemia in dogs?

Population

8 anesthetized, open-chest dogs with cannulated and perfused left anterior descending coronary artery (LAD)

Comparison

Pinacidil infused for 2 minutes; and… vs Baseline and coronary occlusion without…

Design

Preclinical

Authors

IKI. KubotaYamagata UniversityMYMichiyasu YamakiYamagata University HospitalTSTakehiko ShibataTokyo Medical University

Discussion

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Implication

KATP activation may drive ischemic ST elevation in dogs; leaves open translation to human ECG diagnostics or therapies.

Structured PICO

Does the activation of ATP-sensitive K+ channels contribute to ECG ST segment elevation during acute myocardial ischemia in dogs?

P
Population
8 anesthetized, open-chest dogs with cannulated and perfused left anterior descending coronary artery (LAD)
I
Intervention
Pinacidil (10 micrograms.kg-1 x min-1) infused for 2 minutes; and glibenclamide (0.3 mg/kg) intravenous pretreatment before coronary occlusion
C
Comparator
Baseline (before infusion) and coronary occlusion without pretreatment
O
Outcome
ECG ST segment elevation and activation recovery intervalsurrogate

Activation of ATP-sensitive K+ channels during acute myocardial ischemia plays a key role in the emergence of ECG ST segment elevation.

Cite This Study

Kubota et al. (1993) studied this question.

synapsesocial.com/papers/6a1bfd6f0a1f7575939d50echttps://doi.org/10.1161/01.cir.88.4.1845
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activation of cardiac ATP-sensitive K+ current during hypoxia: correlation with tissue ATP levels1991 · 94 citations
  2. 2Ionic currents during hypoxia in voltage-clamped cat ventricular muscle.1980 · 162 citations
  3. 3The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells.1987 · 447 citations
  4. 4Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.1990 · 146 citations
  5. 5BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle.1988 · 192 citations