July 1, 1992CirculationOpen Access

Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning.

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Why the study?

Does intravenous aprikalim improve segment shortening in a canine model of myocardial stunning?

Population

Barbital-anesthetized dogs subjected to 15 minutes of left anterior descending coronary artery occlusion…

Comparison

Intravenous aprikalim given before ischemic… vs Control animals

Design

Preclinical

Follow-up

3 hours of reperfusion

Authors

JAJohn A. AuchampachMedical College of Wisconsin MMM MaruyamaHiroshima University ICIcilio CaveroTotal (France)

Discussion

Member takes

Implication

Aprikalim pretreatment improves postischemic function in canines; leaves open translation of K(ATP) activation to human myocardial stunning.

Structured PICO

Does intravenous aprikalim improve segment shortening in a canine model of myocardial stunning?

Population

Barbital-anesthetized dogs subjected to 15 minutes of left anterior descending (LAD) coronary artery occlusion followed by 3 hours of reperfusion (in vivo model of stunned myocardium)

Intervention

Intravenous aprikalim (10 micrograms/kg plus 0.1 microgram/kg/min) given before ischemic insult or immediately before reperfusion; K(ATP) channel antagonists glibenclamide (0.3 mg/kg or 1.0 mg/kg) or tolbutamide (100 mg/kg)

Comparator

Control animals

Outcome

Segment shortening in the ischemic/reperfused myocardium measured by sonomicrometrysurrogate

Opening myocardial K(ATP) channels with aprikalim prior to ischemia provides a cardioprotective effect and improves contractile function in a canine model of stunned myocardium.

Cite This Study

Auchampach et al. (1992) studied this question.

synapsesocial.com/papers/6a833729292d2964071f31af https://doi.org/10.1161/01.cir.86.1.311

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Implication

Aprikalim pretreatment improves postischemic function in canines; leaves open translation of K(ATP) activation to human myocardial stunning.

Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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