Why the study?
Do K+ATP channel openers (aprikalim and nicorandil) improve recovery of regional contractile function in a canine model of stunned myocardium?
Population
Anesthetized and conscious dogs with a model of stunned myocardium
Comparison
K+ATP channel openers (aprikalim and nicorandil) vs Selective K+ATP antagonist (glyburide)
Design
Preclinical
Authors
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No immediate clinical implications for stunned myocardium; leaves open translation of K+ATP-mediated recovery to human ischemia-reperfusion injury.
Do K+ATP channel openers (aprikalim and nicorandil) improve recovery of regional contractile function in a canine model of stunned myocardium?
K+ATP channel openers aprikalim and nicorandil demonstrate direct cardioprotective actions by enhancing recovery of stunned myocardium in a canine model.
Warltier et al. (1993) studied this question.
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