Key result
Pinacidil induces vascular muscle relaxation and hyperpolarization by increasing Ca2+-dependent big K+ channel conductance.
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Does not guide clinical use; leaves open translation of big K+ channel effects to vascular therapies.
Kent Hermsmeyer (1988) studied this question. Pinacidil was evaluated on K+ conductance and vascular muscle relaxation. Pinacidil caused vascular muscle relaxation and hyperpolarization by increasing K+ conductance associated with the Ca2+-dependent 'big' K+ channel.
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