Key result
Pinacidil cuts action potential duration by ~82% in Purkinje fibers and relaxes veins in vitro.
Population
Canine tissues and isolated cat papillary muscle in vitro
Design
Preclinical
Authors
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Hypothesis-generating for potassium channel openers; clinical translation requires human studies before any practice consideration.
Pinacidil and related potassium channel openers demonstrate a strong correlation between their ability to shorten cardiac action potentials and induce venorelaxation in vitro.
Steinberg et al. (1988) studied this question. Pinacidil was evaluated on Action potential duration and venorelaxation. Pinacidil markedly reduced action potential duration in Purkinje fibers (82% decrease) and ventricular muscle (54% decrease) and relaxed phenylephrine-contracted veins in vitro.
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