Key result
Pinacidil potently relaxes isolated rat aortae independent of endothelium and without elevating cAMP or cGMP.
Why the study?
Does pinacidil induce relaxation and alter cyclic nucleotide levels in isolated rat aortae compared to other vasodilators?
Population
Isolated rat aortae (in vitro preparations)
Comparison
Pinacidil (10(-7)-10(-4) M) vs Nitroglycerin, minoxidil, hydralazine…
Design
Preclinical
Authors
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Animal data on pinacidil should not alter clinical practice; leaves open human mechanistic and therapeutic translation.
Does pinacidil induce relaxation and alter cyclic nucleotide levels in isolated rat aortae compared to other vasodilators?
Pinacidil acts as a potent, endothelium-independent vasodilator in vitro without elevating cAMP or cGMP, suggesting a mechanism of nonspecific arterial vasodilation.
Kauffman et al. (1986) studied Hypertension. Pinacidil vs. Nitroglycerin, minoxidil, hydralazine was evaluated on Aortic relaxation and cyclic nucleotide levels. Pinacidil was a potent relaxant agonist in isolated rat aortae (ED50 = 0.3 microM), independent of an intact endothelium and not associated with elevations in cAMP or cGMP.
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