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October 1, 1989Pharmacology & Toxicology

Effect of Pinacidil on Sympathetic Neuroeffector Transmission in Rabbit Blood Vessels

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ONOve A. NedergaardUniversity of California, Los Angeles

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Implication

Experimental study demonstrates that pinacidil suppresses nerve-evoked contractions and dilates isolated rabbit vessels, indicating distinct prejunctional and postjunctional vascular actions.

Key Points

Investigate the prejunctional and postjunctional effects of pinacidil on sympathetic neuroeffector transmission and vascular smooth muscle tone in isolated rabbit blood vessels.
Measured nerve stimulation-evoked contractile responses and electrical field-stimulated [3H]-noradrenaline overflow in isolated rabbit pulmonary arteries.
Tested pinacidil against contractions induced by noradrenaline, phenylephrine, adrenaline, histamine, serotonin, and potassium in isolated aorta, comparing endothelium-intact and denuded preparations.
Pinacidil (3 x 10^-7 to 3 x 10^-4 M) reversibly suppressed nerve stimulation-evoked contractions in pulmonary artery while paradoxically increasing stimulation-evoked [3H]-noradrenaline overflow at higher concentrations (10^-5 to 3 x 10^-4 M).
Contractions of isolated aorta induced by diverse agonists and potassium were non-competitively antagonized by pinacidil, producing relaxation in preconstricted tissue that was completely independent of the endothelium.

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Ove A. Nedergaard (1989) studied this question.

synapsesocial.com/papers/6a9e28d28908ec8da0acb1ce https://doi.org/10.1111/j.1600-0773.1989.tb01175.x

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Implication

Experimental study demonstrates that pinacidil suppresses nerve-evoked contractions and dilates isolated rabbit vessels, indicating distinct prejunctional and postjunctional vascular actions.

Effect of Pinacidil on Sympathetic Neuroeffector Transmission in Rabbit Blood Vessels

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of Pinacidil on Sympathetic Neuroeffector Transmission in Rabbit Blood Vessels

Discussion

Member takes

Implication

Key Points

Cite This Study

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