Why the study?
Does pinacidil relax smooth muscle via a different mechanism than glyceryl trinitrate in rat and guinea-pig models?
Population
Male Wistar rats and guinea-pigs of either sex. Tissues studied: rat aorta, rat portal vein, guinea-pig…
Comparison
Pinacidil (various concentrations, 0.1-100 µM) vs Glyceryl trinitrate and untreated control tissues
Design
Preclinical
Authors
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Pinacidil's K+ channel opening differs from GTN in rat models; leaves open translation to human vasodilator therapy.
Does pinacidil relax smooth muscle via a different mechanism than glyceryl trinitrate in rat and guinea-pig models?
Pinacidil relaxes smooth muscle by opening apamin-insensitive K+ channels, a mechanism distinct from that of glyceryl trinitrate.
Bray et al. (1987) studied this question.
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