Key result
Pinacidil acts as an efficacious vasodilator of arterial resistance blood vessels but has little venodilator activity in rats, reducing mean arterial pressure in a dose-dependent manner.
Why the study?
Does pinacidil alter arterial and venous resistances and mean circulatory filling pressure in rats?
Population
Rats (pentobarbitone-anaesthetized and conscious intact rats)
Comparison
Pinacidil vs Vehicle
Design
Preclinical
Authors
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Should not inform clinical vasodilator choice; leaves open translation of arterial selectivity from rat models.
Does pinacidil alter arterial and venous resistances and mean circulatory filling pressure in rats?
Pinacidil acts primarily as an arterial vasodilator with minimal effect on venous compliance in rat models.
Waite et al. (1995) studied this question. Pinacidil vs. Vehicle was evaluated on Mean arterial pressure (MAP), mean circulatory filling pressure (MCFP), total peripheral resistance (TPR), cardiac output (CO) and resistance to venous return (Rv). Pinacidil acts as an efficacious vasodilator of arterial resistance blood vessels but has little venodilator activity in rats, reducing mean arterial pressure in a dose-dependent manner.
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