Key result
Intravenous pinacidil significantly reduced mean arterial pressure from 94 to 74 mmHg and increased heart rate from 75 to 106 beats per minute at 10 minutes post-infusion.
Why the study?
Does intravenous pinacidil alter acute haemodynamic parameters in normotensive patients undergoing cardiac catheterisation?
Does intravenous pinacidil alter acute haemodynamic parameters in normotensive patients undergoing cardiac catheterisation?
Intravenous pinacidil acts as a potent peripheral arteriolar vasodilator, significantly reducing systemic vascular resistance and arterial pressure while increasing heart rate and cardiac index in normotensive patients.
Should not change practice in acute settings; extends haemodynamic data but requires randomized confirmation.
The acute haemodynamic effects of i.v. pinacidil 0.2 mg kg-1 infused over 8 min were studied in 10 normotensive patients undergoing cardiac catheterisation. Mean arterial pressure fell from 94 +/- 3 mmHg (mean +/- s.e. mean) before infusion to 74 +/- 3 mmHg at 10 min after commencing infusion (P less than 0.001) and during this time heart rate increased from 75 +/- 4 to 106 +/- 7 beats min-1 (P less than 0.001). Significant changes were recorded until the end of the observation period (70 min after commencing infusion). Cardiac index increased from 3.2 +/- 0.2 to 4.0 +/- 0.2 l min-1 m-2 (P less than 0.001) and systemic vascular resistance fell from 16 +/- 1 to 10 +/- 1 units (P less than 0.001) at 10 min after commencing infusion. By the end of the observation period, the values had returned to pre-infusion levels. Only small changes in pulmonary haemodynamics were observed. These results indicate that pinacidil acts as a peripheral arteriolar vasodilator, and as such may have a role in the treatment of arterial hypertension and of cardiac failure.
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Nicholls et al. (1986) studied Normotensive patients undergoing cardiac catheterization for suspected ischemic heart disease (n=10). Pinacidil vs. Baseline (pre-infusion) was evaluated on Mean arterial pressure at 10 minutes (p=<0.001). Intravenous pinacidil significantly reduced mean arterial pressure from 94 to 74 mmHg and increased heart rate from 75 to 106 beats per minute at 10 minutes post-infusion.
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