Key result
Pinacidil produces dose-related relaxation in dog arteries and veins by interfering with transmembrane calcium influx.
Why the study?
The vasodilatory effects and mechanisms of pinacidil compared to hydralazine and nifedipine in dog arteries were not fully characterized.
Population
Dog arteries and veins in vitro
Comparison
Pinacidil vs hydralazine vs nifedipine
Design
Experimental study using isolated vascular strips and perfused mesenteric vasculature
Authors
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May suggest regional selectivity for pinacidil; leaves open translation to human coronary or renal disease.
Toda et al. (1985) studied this question. Pinacidil vs. Hydralazine and Nifedipine was evaluated on Vasodilatation/relaxation of precontracted arteries. Pinacidil produced dose-related relaxation in dog arteries and veins, likely due to interference with transmembrane calcium influx evoked by receptor stimulation.