Key result
The TGF-β1 CC genotype at codon 10 was significantly associated with an increased susceptibility to chronic heart failure (OR 2.78) compared to healthy controls.
Why the study?
Cytokines including IL-10 and TGF-beta1 appear to contribute to the pathogenesis of chronic heart failure, prompting evaluation of the associations of specific single nucleotide polymorphisms in these genes.
Are IL-10 and TGF-β1 gene polymorphisms associated with susceptibility to chronic heart failure?
Case-Control (n=197)
Are IL-10 and TGF-β1 gene polymorphisms associated with susceptibility to chronic heart failure?
Odds Ratio: 2.78 (95% CI 1.3–5.94)
Absolute Event Rate: 32% vs 14.5%
p-value: p=0.011
Particular genotypes and haplotypes in IL-10 and TGF-β1 genes may render individuals more susceptible to chronic heart failure.
BACKGROUND: As cytokines, including interleukin-10 (IL-10) and transforming growth factor beta 1(TGF-β1) seem to contribute towards the pathogenesis of chronic heart failure (CHF), this study was performed to assess the associations of certain single nucleotide polymorphisms (SNPs) of these genes in a case control study. METHODS: This investigation was carried out to determine the frequency of alleles, genotypes and haplotypes of TGF-β1 and IL-10 single-nucleotide polymorphisms (SNPs) in 57 Iranian patients with CHF compared with 140 healthy subjects using polymerase chain reaction with sequence-specific primers method. RESULTS: Results of the analyzed data divulged a negative association for both TGF-β1 GC genotype at codon 25 (P=0.047) and CT genotype at codon 10 (P=0.018) and CHF proneness. Although, TGF-β1 CC genotype at codon 10 was found to be positively associated with CHF (P=0.011). Moreover, the frequency of IL-10 (-1082, -819, -592) ATA haplotype and TGF-β1 (codon 10, codon 25) TG haplotype were significantly lower in the patients group (P=0.004 and P=0.040, respectively), while TGF-β1 (codon 10, codon 25) CG haplotype was overrepresented in patients with CHF (P=0.007). CONCLUSIONS: Cytokine gene polymorphisms might affect vulnerability to CHF. Particular genotypes and haplotypes in IL-10 and TGF-β1 genes could render individuals more susceptible to CHF.
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Mahmoudi et al. (2019) conducted a case-control in Chronic Heart Failure (n=197). TGF-β1 and IL-10 gene polymorphisms vs. Healthy controls was evaluated on Association of TGF-β1 CC genotype at codon 10 with chronic heart failure (OR 2.78, 95% CI 1.3-5.94, p=0.011). The TGF-β1 CC genotype at codon 10 was significantly associated with an increased susceptibility to chronic heart failure (OR 2.78) compared to healthy controls.
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