The Regulation of the Na+ ‐Ca2+ Exchanger of Heart Sarcolemma
Population
Calf-heart sarcolemma
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May guide in vitro models of cardiac Ca2+ handling; leaves open physiological relevance and clinical translation.
Structured PICO
P
Population
Calf-heart sarcolemma
I
Intervention
Treatment with ATP, Mg2+, and Ca2+; treatment with phosphorylase phosphatase; treatment with Mg2+, Ca2+, and calmodulin; adenosine 5'-[gamma-thio]triphosphate
O
Outcome
Activation and deactivation of Na+/Ca2+ exchangesurrogate
The Na+/Ca2+ exchanger in heart sarcolemma is regulated by a kinase-phosphatase system dependent on Ca2+ and calmodulin.
Cite This Study
Caroni et al. (1983) studied this question.