Review: Relation between beat interval and force of the heartbeat and its clinical implications

W. A. Seed; John M. Walker

doi:10.1093/cvr/22.5.303

May 1, 1988Cardiovascular Research

Review: Relation between beat interval and force of the heartbeat and its clinical implications

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Key Points

To review the physiological mechanisms connecting the interval between heartbeats to myocardial contractile force and examine their clinical relevance in cardiovascular disease.
Synthesized physiological literature and clinical observations on the relationship between beat interval and cardiac contractile force.
Evaluated key mechanisms including mechanical restitution, interval-dependent calcium handling, and post-extrasystolic potentiation.
The duration between consecutive cardiac contractions directly governs intracellular calcium dynamics and the contractile force developed by subsequent beats.
Disturbances in cardiac beat intervals, such as those occurring during extrasystoles or atrial fibrillation, induce marked beat-to-beat variations in ventricular hemodynamic output.

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Implication

This review discusses the physiological relationship between beat interval and the force of the heartbeat, along with its clinical implications.

Abstract

W A SEED, J M WALKER; Review: Relation between beat interval and force of the heartbeat and its clinical implications, Cardiovascular Research, Volume 22, Issue

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Seed et al. (1988) studied this question.

synapsesocial.com/papers/6a79a50b1ba4614d7ff39998 https://doi.org/10.1093/cvr/22.5.303

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Review: Relation between beat interval and force of the heartbeat and its clinical implications

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Review: Relation between beat interval and force of the heartbeat and its clinical implications

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