Key result
Beat-to-beat variations in haemodynamics during atrial fibrillation correlated with in vitro contractile responses (r = 0.72 to 0.81, p<0.0001), demonstrating the role of mechanical restitution.
Population
Patients with atrial fibrillation undergoing cardiac catheterisation, and human myocardial trabeculae from…
Design
Other
Authors
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Supports mechanical restitution in AF haemodynamics beyond filling time; leaves open clinical relevance.
Observational
Effect estimate: r = 0.72 to 0.81
p-value: p=<0.0001
Mechanical restitution contributes to the beat-to-beat changes in stroke volume observed during atrial fibrillation, independent of time-dependent ventricular filling.
S Hardman (1998) conducted an observational in Atrial fibrillation. Preceding R-R interval (mechanical restitution) was evaluated on Correlation between in vivo haemodynamic indices (LVdP/dtmax and aortic velocity integral) and in vitro isometric contractile response (dF/dtmax) (r = 0.72 to 0.81, p=<0.0001). Beat-to-beat variations in haemodynamics during atrial fibrillation correlated with in vitro contractile responses (r = 0.72 to 0.81, p<0.0001), demonstrating the role of mechanical restitution.
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