What is the clinical evidence from this study?

Study design: Cohort. Population: Mild Cognitive Impairment due to Alzheimer's disease (n=559). Intervention: Female sex vs. Male sex. Primary outcome: Mean worsening from baseline in ADAS-Cog11 score among subjects with high likelihood of MCI due to Alzheimer's disease (p=0.006).

May 4, 2018Scientific ReportsOpen Access

Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease

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Key result

Among subjects with a high likelihood of mild cognitive impairment due to Alzheimer's disease, females experienced significantly greater mean worsening in cognitive scores compared to males (11.58 vs 6.87, p=0.006).

Population

559 subjects with late mild cognitive impairment, ages 55-90, from the Alzheimer's Disease Neuroimaging…

Design

Cohort

Follow-up

up to 10 years (mean 43.8 months)

Authors

DSDongwha SohnNational Fisheries Institute KSKatie ShpanskayaDuke University JLJoseph E. LucasVital Research

Discussion

Member takes

Implication

Should not yet change management of MCI due to AD; hypothesis-generating for sex differences in progression.

Study Design

Type

Cohort (n=559)

Multicenter

Yes

Structured PICO

Population

559 older adults (aged 55-90) with late mild cognitive impairment, followed for up to 10 years to assess sex differences in cognitive decline.

Outcome

Change from baseline in Alzheimer's Disease Assessment Scale-Cognitive subscale 11 item (ADAS-Cog11) score

Main Result

Absolute Event Rate: 11.58% vs 6.87%

p-value: p=0.006

Females with a high likelihood of mild cognitive impairment due to Alzheimer's disease experience significantly faster cognitive decline than males.

Limitations

ADNI subjects were recruited largely at clinic-based research sites and may not reflect milder subjects seen in general practice or primary care settings.
Relied on a pathologically validated tau/Aβ42 ratio cut-off as a surrogate to identify biomarker positive MCI subjects, as there is no perfect in-vivo method to identify MCI due to AD.
Longitudinal sex differences were driven primarily by ADNI-1 data and were not significant in ADNI-2, possibly due to differences in sample size, follow-up duration, or selection bias.
The ADAS-Cog11 test is not necessarily perfectly balanced across all cognitive domains, and females may show a slightly different profile on this test.

Cite This Study

Sohn et al. (2018) conducted a cohort in Mild Cognitive Impairment due to Alzheimer's disease (n=559). Female sex vs. Male sex was evaluated on Mean worsening from baseline in ADAS-Cog11 score among subjects with high likelihood of MCI due to Alzheimer's disease (p=0.006). Among subjects with a high likelihood of mild cognitive impairment due to Alzheimer's disease, females experienced significantly greater mean worsening in cognitive scores compared to males (11.58 vs 6.87, p=0.006).

synapsesocial.com/papers/6a79ab6c8d250a4360f3af82 https://doi.org/10.1038/s41598-018-25377-w

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Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider