September 20, 2008European Journal of Clinical Investigation
Effect of weight loss on markers of triglyceride‐rich lipoprotein metabolism in the metabolic syndrome
Key result
Weight loss by dietary restriction significantly decreased plasma apoC-III (-33%), apoB-48 (-37%), VLDL-apoB (-43%), and RLP-cholesterol (-48%) compared to weight maintenance (P<0.05).
Why the study?
Does weight loss by dietary restriction improve markers of triglyceride-rich lipoprotein metabolism and plasma adipocytokines in men with metabolic syndrome?
Population
35 men with metabolic syndrome (MetS)
Comparison
Weight loss by dietary restriction for 16 weeks vs Weight maintenance
Design
RCT, randomized
Follow-up
16 weeks
Authors
Discussion
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Member takes
Implication
Supports dietary weight loss in metabolic syndrome; confirms RCT benefits on TRL metabolism markers.
Study Design
Type
RCT (n=35)
Randomization
randomized
Structured PICO
Does weight loss by dietary restriction improve markers of triglyceride-rich lipoprotein metabolism and plasma adipocytokines in men with metabolic syndrome?
P
Population
35 men with metabolic syndrome participated in a 16-week randomized controlled dietary intervention study.
I
Intervention
Weight loss by dietary restriction for 16 weeks
C
Comparator
Weight maintenance
O
Outcome
Markers of triglyceride-rich lipoprotein (TRL) metabolism and plasma adipocytokines (apoC-III, apoB-48, RLP-cholesterol, total adiponectin, HMW adiponectin, RBP-4)surrogate
Main Result
p-value: p=<0.05
In men with metabolic syndrome, weight loss via dietary restriction significantly improves markers of triglyceride-rich lipoprotein metabolism and adipocytokine profiles.
Cite This Study
Chan et al. (2008) conducted an RCT in Metabolic syndrome (n=35). Weight loss by dietary restriction vs. Weight maintenance was evaluated on Markers of triglyceride-rich lipoprotein metabolism and plasma adipocytokines (p=<0.05). Weight loss by dietary restriction significantly decreased plasma apoC-III (-33%), apoB-48 (-37%), VLDL-apoB (-43%), and RLP-cholesterol (-48%) compared to weight maintenance (P<0.05).