Key result
Post-pulmonary embolism syndrome spans diverse clinical phenotypes from persistent dyspnea to CTEPH.
Why the study?
Post-PE syndrome (PPES) frequently affects survivors with persistent dyspnea and functional impairment, but its definition is evolving and encompasses a spectrum of disease phenotypes.
This review outlines the evolving definition, phenotypes, physiological basis, diagnosis, and management of post-pulmonary embolism syndrome.
May warrant systematic post-PE follow-up to detect common PPES; leaves open standardized definitions and prospective trials.
The acute phase of pulmonary embolism (PE) may be a severe and potentially life-threatening condition. Moreover, long-term consequences following the acute phase can significantly impact a patient's daily life. A systematic approach to PE follow-up can identify potential complications following acute PE. Post-PE syndrome (PPES) is a common occurrence among survivors experiencing persistent dyspnea and impaired functional status. While the exact definition is evolving, it encompasses a spectrum of disease phenotypes that may occur following an acute PE, which ranges from dyspnea, functional limitation, or cardiac impairment to chronic thromboembolic disease and chronic thromboembolic pulmonary hypertension. This review will describe the different PPES phenotypes, including their physiological basis, diagnosis and workup, and management following acute PE.
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Lashari et al. (2026) conducted a review in Post-Pulmonary Embolism Syndrome. Post-pulmonary embolism syndrome encompasses a spectrum of disease phenotypes following acute pulmonary embolism, ranging from dyspnea to chronic thromboembolic pulmonary hypertension.
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