Key result
Post-PE syndrome is a frequent and clinically relevant long-term complication of acute pulmonary embolism that remains largely understudied.
Post-PE syndrome is a frequent and clinically relevant long-term complication of acute pulmonary embolism that requires further study to predict its development and evaluate treatments like cardiopulmonary rehabilitation.
May heighten post-PE surveillance in follow-up; leaves open validated predictors and rehabilitation trials.
In addition to among others major bleeding from anticoagulant therapy and recurrent venous thromboembolism (VTE), patients who survived acute pulmonary embolism (PE) face an increased risk of chronic functional limitations and decreased quality of life. In recent years, this latter complications have been better framed within the evolving definition of "post-PE syndrome" of which chronic thromboembolic pulmonary hypertension (CTEPH) represents the most extreme presentation. The post-PE syndrome in all its aspects is a frequent and clinically relevant long-term complication of PE but -except for CTEPH- has been largely understudied. There is great need to better define and understand the natural course of acute PE, to predict the development of the post-PE syndrome and to evaluate the potential benefits evolving treatments such as cardiopulmonary rehabilitation.
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Barco et al. (2018) conducted a review in acute pulmonary embolism (PE). Post-PE syndrome is a frequent and clinically relevant long-term complication of acute pulmonary embolism that remains largely understudied.
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