Key result
This editorial discusses an updated review on the pharmacological properties, efficacy, and safety of thiazide diuretics in patients with advanced chronic kidney disease.
Why the study?
Are thiazide diuretics efficacious and safe in patients with advanced chronic kidney disease?
Are thiazide diuretics efficacious and safe in patients with advanced chronic kidney disease?
This editorial highlights an updated review on the pharmacological properties, efficacy, and safety of thiazide diuretics in patients with advanced chronic kidney disease.
The thiazide class diuretics are first-line agents for managing hypertension either as monotherapy or as a fixed-dose combination with other antihypertensive drugs. However, despite the extensive experience with these drugs for >60 years, there is general reluctance to use these agents in patients with advanced chronic kidney disease (CKD) because of concerns about their efficacy and safety as kidney function declines. In this issue of Clinical Kidney Journal, Minutolo et al. performed an updated review of the pharmacological properties, efficacy and side effects and randomized controlled trials that tested these drugs in patients with CKD.
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Espriella et al. (2022) conducted an editorial in Chronic kidney disease (CKD). Thiazide class diuretics was evaluated. This editorial discusses an updated review on the pharmacological properties, efficacy, and safety of thiazide diuretics in patients with advanced chronic kidney disease.
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