Why the study?
Hypertension is prevalent and worsens with CKD progression, but clear data supporting blood pressure targets and specific antihypertensive drug combinations are lacking, risking underuse of older drug classes.
Do thiazide diuretics have a role in managing hypertension in patients with chronic kidney disease?
Do thiazide diuretics have a role in managing hypertension in patients with chronic kidney disease?
This article discusses the potential overlooked role of older antihypertensive classes, such as thiazide diuretics, in managing blood pressure in patients with chronic kidney disease.
Hypertension is both a cause and consequence of chronic kidney disease (CKD). As such, the prevalence of hypertension is high among CKD patients and the incidence increases as their kidney disease progresses. Given the high risk of mortality, morbidity and risk of progression to end-stage renal failure, blood pressure management remains a key focus in managing CKD patients. However, without strong definitive evidence for blood pressure targets, or clear data to support the precise combination of antihypertensive medications, practice variance increases as the number of drugs available to treat hypertension increases and older drug classes may be overlooked.
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Haroon et al. (2023) studied this question.
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