Key result
A Systemic Inflammatory Response Index (SIRI) value of 1.16 was 77% sensitive and 55% specific for predicting fractional flow reserve positivity in intermediate coronary stenosis.
Why the study?
SIRI indicates coronary artery disease presence and severity, but its relationship with the functional significance of FFR in intermediate coronary stenosis required evaluation.
Does the Systemic Inflammatory Response Index (SIRI) predict Fractional Flow Reserve (FFR) positivity in patients with intermediate coronary artery stenosis?
Population
294 patients with 50–70% coronary stenosis who underwent FFR measurement
Comparison
Positive FFR vs negative FFR
Authors
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SIRI may support noninvasive risk stratification in intermediate stenosis; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=294)
Does the Systemic Inflammatory Response Index (SIRI) predict Fractional Flow Reserve (FFR) positivity in patients with intermediate coronary artery stenosis?
p-value: p=<0.05
The Systemic Inflammatory Response Index (SIRI) may serve as a useful, easily accessible biomarker for predicting hemodynamically significant intermediate coronary stenosis as assessed by FFR.
Akyel et al. (2025) conducted an observational in Intermediate coronary artery stenosis (n=294). Systemic Inflammatory Response Index (SIRI) was evaluated on Fractional Flow Reserve (FFR) positivity (p=<0.05). A Systemic Inflammatory Response Index (SIRI) value of 1.16 was 77% sensitive and 55% specific for predicting fractional flow reserve positivity in intermediate coronary stenosis.
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