May 12, 2016PLoS ONEOpen Access

Plasma Levels of Monocyte Chemoattractant Protein-1, n-Terminal Fragment of Brain Natriuretic Peptide and Calcidiol Are Independently Associated with the Complexity of Coronary Artery Disease

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Coronary artery disease (n=270). Intervention: Plasma levels of calcidiol, MCP-1, and NT-proBNP vs. Reference biomarker levels. Primary outcome: High-grade coronary artery calcification (OR 0.57, 95% CI 0.36-0.90, p=0.013).

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Key result

Higher plasma levels of MCP-1 and NT-proBNP independently predicted greater coronary artery disease complexity, while higher calcidiol levels were protective against high-grade calcification (OR 0.57 per 10 ng/mL increase).

Population

270 patients with coronary disease that had an acute coronary syndrome six months before, median age 65.0…

Design

Cohort, The investigators who performed the analytical studies were unaware of…

Follow-up

median 1.79 (0.94-2.86) years

Authors

RMRoberto Martín-ReyesHospital La Luz JPJuan Antonio Franco PeláezHospital Universitario Fundación Jiménez Díaz ÓLÓscar LorenzoDiabetes Australia

Discussion

Member takes

Implication

May aid CAD risk stratification; leaves open whether modulating these biomarkers alters outcomes.

Study Design

Type

Observational (n=270)

Multicenter

Structured PICO

Population

270 patients with coronary artery disease who experienced an acute coronary syndrome six months prior, followed for a median of 1.79 years.

Exposure

Measurement of plasma biomarkers (MCP-1, NT-proBNP, calcidiol, etc.) and assessment of Syntax Score (SS) and coronary artery calcification (CAC) at 6 months post-ACS.

Outcome

Syntax Score (SS) and coronary artery calcification (CAC) severity, and a composite outcome of ACS, stroke, or transient ischemic attack during follow-up.surrogate

Main Result

Odds Ratio: 0.57 (95% CI 0.36–0.9)

p-value: p=0.013

Elevated MCP-1 and NT-proBNP are associated with higher coronary anatomical complexity (Syntax Score), while low calcidiol is associated with greater coronary calcification in patients 6 months post-ACS.

Limitations

Plasma determination was performed six months after the coronary angiogram, potentially missing acute changes.
Limited sample size and low number of clinical events during follow-up.
Observational study design limits the ability to establish causal relationships.
observational study
therapy with statins recorded reflects the treatment given to the patients after the coronary angiogram, not in the previous years where the complexity of CAD was established

Cite This Study

Martín-Reyes et al. (2016) conducted an observational in Coronary artery disease (n=270). Plasma levels of calcidiol, MCP-1, and NT-proBNP vs. Reference biomarker levels was evaluated on High-grade coronary artery calcification (OR 0.57, 95% CI 0.36-0.90, p=0.013). Higher plasma levels of MCP-1 and NT-proBNP independently predicted greater coronary artery disease complexity, while higher calcidiol levels were protective against high-grade calcification (OR 0.57 per 10 ng/mL increase).

synapsesocial.com/papers/6a79bcf806bbdce361020abb https://doi.org/10.1371/journal.pone.0152816

Topics

Coronary artery disease

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Plasma Levels of Monocyte Chemoattractant Protein-1, n-Terminal Fragment of Brain Natriuretic Peptide and Calcidiol Are Independently Associated with the Complexity of Coronary Artery Disease

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Plasma Levels of Monocyte Chemoattractant Protein-1, n-Terminal Fragment of Brain Natriuretic Peptide and Calcidiol Are Independently Associated with the Complexity of Coronary Artery Disease

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

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Topics

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