Key result
Higher carotid intimal medial thickness was significantly associated with a faster decline in cognitive function over 3 years in patients with mild to moderate Alzheimer's disease (ADAS-cog b=-0.68).
Population
521 patients with mild to moderate Alzheimer's disease, mean age 69.2, 45.6% male, from Chongqing, China…
Design
Cohort
Follow-up
3 years
Authors
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Higher carotid IMT was associated with faster cognitive decline in AD; leaves open causal role and need for interventional confirmation.
Cohort (n=521)
Yes
Effect estimate: b=-0.68
p-value: p=0.036
Carotid atherosclerosis, as measured by intima-media thickness, is a significant predictor of accelerated cognitive decline in patients with mild to moderate Alzheimer's disease.
Jing Xiang (2017) conducted a cohort in Mild to moderate Alzheimer's disease (n=521). Carotid intimal medial thickness (IMT) vs. Lower carotid IMT was evaluated on Change in Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) over time (IMTxAge interaction) (b=-0.68, p=0.036). Higher carotid intimal medial thickness was significantly associated with a faster decline in cognitive function over 3 years in patients with mild to moderate Alzheimer's disease (ADAS-cog b=-0.68).
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