Why the study?
Is severe internal carotid artery stenosis associated with faster progression of cognitive impairment in patients with Alzheimer's disease?
Population
411 patients with Alzheimer's disease
Comparison
Severe internal carotid artery stenosis vs No significant carotid artery stenosis
Design
Cohort
Follow-up
12 months
Authors
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Severe carotid stenosis was associated with dementia progression in AD; leaves open whether revascularization alters trajectory.
Is severe internal carotid artery stenosis associated with faster progression of cognitive impairment in patients with Alzheimer's disease?
Severe internal carotid artery stenosis is associated with a faster rate of cognitive decline in patients with Alzheimer's disease, suggesting a potential role for cerebral hemodynamic evaluation and revascularization.
Silvestrini et al. (2011) studied this question.
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