Key result
Abnormal breath-holding index linked to progressive cognitive decline in asymptomatic severe bilateral carotid stenosis.
Why the study?
The risk and mechanisms of cognitive deterioration in patients with bilateral asymptomatic severe internal carotid artery stenosis were not well characterized.
Comparison
Patients with normal vs unilaterally vs bilaterally abnormal cerebral hemodynamics
Design
Prospective cohort study
Follow-up
3 years
Authors
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Impaired cerebral vasoreactivity was associated with cognitive decline in bilateral asymptomatic carotid stenosis; leaves open whether hemodynamic testing aids risk stratification.
Cohort (n=159)
p-value: p=<0.0001
In patients with asymptomatic bilateral severe internal carotid artery stenosis, impaired cerebral hemodynamics (abnormal breath-holding index) is strongly associated with cognitive deterioration over 3 years.
Buratti et al. (2014) conducted a cohort in Bilateral asymptomatic severe internal carotid artery stenosis (n=159). Abnormal breath-holding index vs. Normal breath-holding index was evaluated on Decrease in Mini-Mental State Examination score (p=<0.0001). An abnormal breath-holding index progressively increased the risk of cognitive decline in patients with asymptomatic bilateral severe internal carotid artery stenosis (P<0.0001).
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