September 1, 2000AJP Cell Physiology

Two distinct inactivation processes related to phosphorylation in cardiac L-type Ca2+ channel currents

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Population

Cardiac L-type Ca2+ channels (studied using whole cell patch-clamp technique with Na+ as the current carrier)

Comparison

Isoproterenol, H-89, and cAMP vs Baseline/control conditions

Design

Preclinical

Authors

SMSayaka MitaraiUniversity of Nagasaki MKMuneshige KaibaraNagasaki University KYKatsusuke YanoNagasaki University

Discussion

Member takes

Implication

May refine models of L-type Ca channel gating in animals; leaves open translation to human electrophysiology or therapies.

Structured PICO

Population

Cardiac L-type Ca2+ channels (studied using whole cell patch-clamp technique with Na+ as the current carrier)

Intervention

Isoproterenol (100 nM), H-89 (protein kinase inhibitor), and cAMP (500 μM)

Comparator

Baseline/control conditions

Outcome

Inactivation process of macroscopic cardiac L-type Ca2+ channel currentssurrogate

Phosphorylation of cardiac L-type Ca2+ channels converts their inactivation kinetics from a two-component process to a single slow component with different voltage dependency.

Cite This Study

Mitarai et al. (2000) studied this question.

synapsesocial.com/papers/6a79c12d1ba4614d7ff3a587 https://doi.org/10.1152/ajpcell.2000.279.3.c603

View Full Paper

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Two distinct inactivation processes related to phosphorylation in cardiac L-type Ca2+ channel currents

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Two distinct inactivation processes related to phosphorylation in cardiac L-type Ca2+ channel currents

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider