Key result
In human atrial myocytes, Ca2+-dependent mechanisms predominate over voltage-dependent mechanisms for L-type Ca2+ channel inactivation during the time course of an action potential.
In human atrial myocytes, L-type calcium channel inactivation is primarily Ca2+-dependent, with SR-released Ca2+ driving early rapid inactivation and permeating Ca2+ driving the slower phase.
No takes yet. Share an insight, caveat, or question.
Extends Ca2+-dependent inactivation data to human atrial myocytes; leaves open in vivo validation and arrhythmia relevance.
Sun et al. (1997) studied this question. Ryanodine and Ca2+ availability manipulation was evaluated on Mechanisms of L-type Ca2+ channel inactivation. In human atrial myocytes, Ca2+-dependent mechanisms predominate over voltage-dependent mechanisms for L-type Ca2+ channel inactivation during the time course of an action potential.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: