Key result
Intravenous amiodarone administered intraoperatively during valvular surgery significantly increased pulmonary artery pressure, central venous pressure, and pulmonary vascular resistance index (p<0.05).
Why the study?
Does intraoperative intravenous amiodarone alter right ventricular function in patients undergoing elective valvular surgery?
Population
Elective cardiac surgical patients undergoing valvular surgery
Comparison
Intravenous amiodarone vs Intravenous placebo (loading dose and infusion)
Design
RCT, randomized
Follow-up
acute intraoperative (before and after bolus)
Authors
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Intraoperative IV amiodarone may elevate pulmonary pressures in valvular surgery; warrants monitoring and extends acute RV hemodynamic data.
RCT
Randomized
Does intraoperative intravenous amiodarone alter right ventricular function in patients undergoing elective valvular surgery?
Acute intraoperative administration of intravenous amiodarone in valvular surgery patients alters right ventricular diastolic properties with minimal negative inotropic effect on systolic function.
Denault et al. (2014) conducted an RCT in Valvular heart disease. Intravenous amiodarone vs. Placebo was evaluated on Right ventricular (RV) systolic and diastolic function. Intravenous amiodarone administered intraoperatively during valvular surgery significantly increased pulmonary artery pressure, central venous pressure, and pulmonary vascular resistance index (p<0.05).
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