What question did this study set out to answer?

To examine diagnostic delays in sporadic Creutzfeldt-Jakob disease caused by initial focal neurological deficits and rigid application of historical diagnostic criteria.

February 15, 2013Neurology InternationalOpen Access

Sporadic Creutzfeldt-Jakob disease with focal findings: caveats to current diagnostic criteria

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To examine diagnostic delays in sporadic Creutzfeldt-Jakob disease caused by initial focal neurological deficits and rigid application of historical diagnostic criteria.
Clinical evaluation and follow-up of a 61-year-old male presenting with epilepsia partialis continua, left hemiparesis, and hemisensory neglect.
Serial diagnostic investigations including diffusion-weighted brain magnetic resonance imaging, repeated electroencephalography across 20 days, and brain biopsy.
Initial brain MRI showed asymmetric cortical restricted diffusion spreading contralateral over time, while EEG evolved from right-sided periodic lateralized epileptiform discharges to periodic sharp wave complexes by day 20.
Brain biopsy confirmed definite sporadic Creutzfeldt-Jakob disease after the patient rapidly progressed to generalized myoclonus and akinetic mutism within 7 weeks of symptom onset.

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Implication

Case report reveals atypical focal presentation in sporadic Creutzfeldt-Jakob disease, highlighting limitations of rigid 1998 World Health Organization criteria.

Cite This Study

Mader et al. (2013) studied this question.

synapsesocial.com/papers/6a79c99a02ab7a73dd028ec6 https://doi.org/10.4081/ni.2013.e1

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Implication

Case report reveals atypical focal presentation in sporadic Creutzfeldt-Jakob disease, highlighting limitations of rigid 1998 World Health Organization criteria.

Sporadic Creutzfeldt-Jakob disease with focal findings: caveats to current diagnostic criteria

Key Points

Discussion

Implication

Cite This Study

Sporadic Creutzfeldt-Jakob disease with focal findings: caveats to current diagnostic criteria

Key Points

Discussion

Implication

Cite This Study

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