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This case aims to underline the atypical presentation of Creutzfeldt-Jakob disease and the importance of differential diagnosis in cognitive decline.

449: A Curious and Misleading Case of Cognitive Decline: Creutzfeldt-Jakob Disease

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This case aims to underline the atypical presentation of Creutzfeldt-Jakob disease and the importance of differential diagnosis in cognitive decline.
Case report of a 64-year-old male with cognitive decline and altered mental status
MRI and lumbar puncture examination performed to assess neurological condition
Consultation with neurology for potential autoimmune encephalitis management
Postmortem autopsy confirmed diagnosis of sporadic Creutzfeldt-Jakob disease
CSF analysis showed elevated Tau protein and 14-3-3 levels
Patient did not respond to treatment options despite high-dose steroids and anticonvulsants

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A case report reveals cognitive decline in a 64-year-old male, suggesting the need for differential diagnosis awareness.

Panwar et al. (2026) studied this question.

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