What does this research mean for the field?

Sporadic Creutzfeldt-Jakob disease can present with rapidly progressive behavioral changes and initially non-specific clinical findings, requiring a high index of suspicion and advanced diagnostic modalities like RT-QuIC, tau protein analysis, and repeat MRI for accurate identification. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This report aims to highlight the rapid behavioral changes in a patient with sporadic CJD and the challenges in diagnosis.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

B48-05 Rapidly Progressive Behavior Changes: A Case of Sporadic CJD

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This report aims to highlight the rapid behavioral changes in a patient with sporadic CJD and the challenges in diagnosis.
Case report of a 64-year-old male with altered mental status and neurological symptoms.
Diagnostic imaging included MRI and EEG; lumbar puncture performed for CSF analysis.
Treatment involved high-dose steroids and intravenous immunoglobulin therapy.
MRI showed signal changes suggestive of sporadic CJD with elevated T-tau protein levels (4095) and positive RT-QuIC.
Patient exhibited rapid clinical decline without response to treatment, ultimately passing away within one month.
Diagnosis relied on clinical criteria, CSF findings, MRI results, and elevated tau protein levels.

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Implication

Case report reveals the challenging diagnosis and rapid progression of behavioral changes in sporadic CJD.

Cite This Study

Khan et al. (2026) studied this question.

synapsesocial.com/papers/6a0d50aff03e14405aa9ca4a https://doi.org/10.1093/ajrccm/aamag162.3212

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B48-05 Rapidly Progressive Behavior Changes: A Case of Sporadic CJD

Key Points

Discussion

Implication

Cite This Study

B48-05 Rapidly Progressive Behavior Changes: A Case of Sporadic CJD

Key Points

Discussion

Implication

Cite This Study

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