Why the study?
Does oral isosorbide-5-mononitrate or nifedipine prevent spontaneous and induced vasospastic myocardial ischaemia compared to placebo in patients with angina at rest?
Does oral isosorbide-5-mononitrate or nifedipine prevent spontaneous and induced vasospastic myocardial ischaemia compared to placebo in patients with angina at rest?
Both oral isosorbide-5-mononitrate and nifedipine are highly and equally effective in reducing spontaneous and ergonovine-induced myocardial ischaemia in patients with rest angina.
Answers are grounded in this paper and cite their sources.
Either agent offers effective therapy for vasospastic angina; confirms equivalent efficacy of nitrates and calcium channel blockers versus placebo.
This study was designed to assess the efficacy of oral nifedipine as compared to oral isosorbide-5-mononitrate in the prevention of spontaneous and induced vasospastic myocardial ischaemia. Twenty-one patients admitted to the Coronary Care Unit as a result of angina at rest underwent both Holter monitoring and an echo-ergonovine test during placebo and following either isosorbide-5-mononitrate or nifedipine according to a double-blind randomized trial. Both drugs caused a statistically significant reduction in spontaneous (87% and 95%, respectively) and induced ischaemic attacks (66% and 75%, respectively). No significant difference was found between the two drugs.
No takes yet. Share an insight, caveat, or question.
Lombardi et al. (1993) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: