Key result
The ACTN3 'R' allele and PPARα 'C' allele were more frequent in elite adolescent Egyptian athletes compared to sedentary controls.
Why the study?
PPARα and ACTN3 have the potential to influence human athletic performance, prompting an evaluation of their genotype frequencies among Egyptian adolescent athletes.
Are polymorphisms in ACTN3 and PPARα associated with elite athletic performance in Egyptian adolescents?
Case-Control (n=228)
Are polymorphisms in ACTN3 and PPARα associated with elite athletic performance in Egyptian adolescents?
Polymorphisms in ACTN3 and PPARα are significantly more frequent in elite adolescent Egyptian athletes compared to sedentary controls, suggesting a genetic component to athletic performance.
Answers are grounded in this paper and cite their sources.
May support genetic screening for talent ID in Egyptian youth athletes; hypothesis-generating and requires prospective validation before adoption.
Background: Athletic performance is a complex phenotype affected by individual traits, environmental conditions, training, and genetics. The peroxisome proliferator-activated receptor-alpha (PPARα) and alpha-actinin-3 (ACTN3) are two genes with the potential to influence human performance. The objective of the present study was to assess the genotype frequencies of ACTN3 (R/X) and PPARα (G/C) and to conduct a comparison of these frequencies among Egyptian adolescent athletes. Methods: This case–control study involved 228 individuals (118 elite-level athletes and 110 sedentary controls). Results: This study identified a statistically significant increase in the frequencies of the ACTN3 ‘R’ allele (77.5% compared to 55.9%; p < 0.001) and the PPARα ‘C’ allele (86.4% compared to 14.1%; p < 0.001) among athletes relative to the control groups. A similar pattern was noted for adolescent athletes in comparison to the control group in terms of both the R/R genotype (61.9% compared to 27.3%; p < 0.001) and the C/C genotype (80.5% compared to 2.7%; p < 0.001). In conclusion, these results imply that polymorphisms in ACTN3 and PPARα could be significant predictors for assessing the performance of adolescent Egyptian athletes.
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Ramadan et al. (2025) conducted a case-control in Athletic performance (n=228). ACTN3 and PPARα polymorphisms vs. Sedentary controls was evaluated on ACTN3 'R' allele frequency (p=< 0.001). The ACTN3 'R' allele and PPARα 'C' allele were more frequent in elite adolescent Egyptian athletes compared to sedentary controls.
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