Key result
The PPARGC1A Ser/Ser genotype was significantly associated with being a powerlifter compared to controls (OR 2.11; 95% CI 1.09-4.09; P=0.026).
Why the study?
Are ACE, ACTN3, and PPARGC1A gene polymorphisms associated with strength/power-oriented athlete status in European athletes?
Population
161 European Caucasian athletes from Russia and Lithuania and 1,202 controls
Comparison
ACE, ACTN3 and PPARGC1A gene polymorphisms vs 1,202 controls
Design
Case-control
Authors
Loading...
These genotype associations with power athlete status should not guide clinical decisions; hypothesis-generating for prospective validation in European cohorts.
Case-Control (n=1,363)
Yes
Are ACE, ACTN3, and PPARGC1A gene polymorphisms associated with strength/power-oriented athlete status in European athletes?
Odds Ratio: 2.11 (95% CI 1.09–4.09)
p-value: p=0.026
ACE and PPARGC1A gene polymorphisms, but not ACTN3, are associated with strength and power athletic status in European cohorts.
Ginevičienė et al. (2016) conducted a case-control in Strength and power athletes (n=1,363). ACE, ACTN3 and PPARGC1A gene polymorphisms vs. Controls was evaluated on Strength/power-oriented athletes' status (OR 2.11, 95% CI 1.09-4.09, p=0.026). The PPARGC1A Ser/Ser genotype was significantly associated with being a powerlifter compared to controls (OR 2.11; 95% CI 1.09-4.09; P=0.026).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: