What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Sport performance. Intervention: ACE II genotype vs. ACE D allele carriage (DD + ID). Primary outcome: Physical performance (OR 1.23, 95% CI 1.05-1.45).

January 24, 2013PLoS ONEOpen Access

The Association of Sport Performance with ACE and ACTN3 Genetic Polymorphisms: A Systematic Review and Meta-Analysis

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Why the study?

Do ACE I/D and ACTN3 R577X genetic polymorphisms associate with sport performance in athletes compared to sedentary controls?

Population

Athletes and sedentary controls from 42 included case-control or cohort studies

Comparison

ACE II genotype and ACTN3 R allele vs ACE D allele carriage and ACTN3 X allele carriage

Design

Meta-analysis

Key result

The ACE II genotype was significantly associated with an increased possibility of physical performance compared to D allele carriage (OR 1.23), particularly in endurance athletes.

Authors

FMFang Ma YYYu Yang XLXiangwei Li

Discussion

Member takes

Overview

Supports genetic contribution to endurance performance; confirms prior associations while leaving clinical utility of genotyping open.

Study Design

Type

Meta-Analysis

Structured PICO

Do ACE I/D and ACTN3 R577X genetic polymorphisms associate with sport performance in athletes compared to sedentary controls?

Population

Athletes and sedentary controls from 42 included case-control or cohort studies (25 addressing ACE, 23 addressing ACTN3, with 6 overlapping)

Intervention

ACE II genotype and ACTN3 R allele (genetic polymorphisms)

Comparator

ACE D allele carriage (DD+ID) and ACTN3 X allele carriage (XX+RX)

Outcome

Sport performance (categorized into endurance and power events)

Main Result

Effect estimate: OR 1.23 (95% CI 1.05-1.45)

The ACE II genotype is significantly associated with endurance sport performance, while the ACTN3 R allele is associated with power events, supporting the influence of genetic profiles on human physical performance.

Limitations

The potential confounding effect of performance level was not considered because of the different criterions of elite athletes.
Crude division of ethnic groups into Asian, African, and Western may make the analyses prone to bias.
Only articles providing data on both athletes and sedentary controls were included, which might introduce potential selection bias.
Phenotypic heterogeneity cannot be excluded due to the variety of definitions of endurance/power events and mixed sport disciplines.
Potential confounding effect of performance level due to different criterions of elite athletes
Crude division of ethnic groups into 'Asian', 'African' and 'Western' may make analyses prone to bias
Selection bias from including only articles providing data on both athletes and sedentary controls
Publication bias where studies reporting negative genetic associations are less likely to be published
Phenotypic heterogeneity due to variety of definitions of endurance/power events and mixed sport disciplines

Cite This Study

Ma et al. (2013) conducted a meta-analysis in Sport performance. ACE II genotype vs. ACE D allele carriage (DD + ID) was evaluated on Physical performance (OR 1.23, 95% CI 1.05-1.45). The ACE II genotype was significantly associated with an increased possibility of physical performance compared to D allele carriage (OR 1.23), particularly in endurance athletes.

synapsesocial.com/papers/6a10cd6bed67694fb09f762f https://doi.org/10.1371/journal.pone.0054685

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January 24, 2013PLoS ONEOpen Access

The Association of Sport Performance with ACE and ACTN3 Genetic Polymorphisms: A Systematic Review and Meta-Analysis

View Full Paper

Ask AI

Bookmark

Why the study?

Do ACE I/D and ACTN3 R577X genetic polymorphisms associate with sport performance in athletes compared to sedentary controls?

Population

Athletes and sedentary controls from 42 included case-control or cohort studies

Comparison

ACE II genotype and ACTN3 R allele vs ACE D allele carriage and ACTN3 X allele carriage

Design

Meta-analysis

Key result

The ACE II genotype was significantly associated with an increased possibility of physical performance compared to D allele carriage (OR 1.23), particularly in endurance athletes.

Authors

FMFang Ma YYYu Yang XLXiangwei Li

Discussion

Member takes

Overview

Supports genetic contribution to endurance performance; confirms prior associations while leaving clinical utility of genotyping open.

Study Design

Type

Meta-Analysis

Structured PICO

Do ACE I/D and ACTN3 R577X genetic polymorphisms associate with sport performance in athletes compared to sedentary controls?

Population

Athletes and sedentary controls from 42 included case-control or cohort studies (25 addressing ACE, 23 addressing ACTN3, with 6 overlapping)

Intervention

ACE II genotype and ACTN3 R allele (genetic polymorphisms)

Comparator

ACE D allele carriage (DD+ID) and ACTN3 X allele carriage (XX+RX)

Outcome

Sport performance (categorized into endurance and power events)

Main Result

Effect estimate: OR 1.23 (95% CI 1.05-1.45)

Limitations

The potential confounding effect of performance level was not considered because of the different criterions of elite athletes.
Crude division of ethnic groups into Asian, African, and Western may make the analyses prone to bias.
Only articles providing data on both athletes and sedentary controls were included, which might introduce potential selection bias.
Phenotypic heterogeneity cannot be excluded due to the variety of definitions of endurance/power events and mixed sport disciplines.
Potential confounding effect of performance level due to different criterions of elite athletes
Crude division of ethnic groups into 'Asian', 'African' and 'Western' may make analyses prone to bias
Selection bias from including only articles providing data on both athletes and sedentary controls
Publication bias where studies reporting negative genetic associations are less likely to be published
Phenotypic heterogeneity due to variety of definitions of endurance/power events and mixed sport disciplines

Cite This Study

synapsesocial.com/papers/6a10cd6bed67694fb09f762f https://doi.org/10.1371/journal.pone.0054685

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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