Key result
Healthy newborns exhibited a significantly lower index of synchronization of low-frequency oscillations (20.1%) compared to healthy adults (33.2%, p=0.023), indicating immaturity of vegetative regulation.
Cross-Sectional (n=75)
Absolute Event Rate: 20.1% vs 33.2%
p-value: p=0.023
Healthy newborns exhibit lower synchronization between baroreflex regulation of heart rhythm and peripheral blood filling compared to adults, likely due to the immaturity of the autonomic nervous system.
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Requires age-adjusted autonomic norms in neonates; leaves open validation of clinical utility.
Panina et al. (2018) conducted a cross-sectional in Healthy (n=75). Newborn status vs. Healthy adults was evaluated on Index of synchronization of low-frequency oscillations (S index) (p=0.023). Healthy newborns exhibited a significantly lower index of synchronization of low-frequency oscillations (20.1%) compared to healthy adults (33.2%, p=0.023), indicating immaturity of vegetative regulation.
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