Key result
Graded lower body negative pressure increased the number of MSNA bursts per low-frequency cycle from 2.55 ± 0.68 at baseline to 5.44 ± 1.56 at -40 mmHg.
Population
11 healthy, normotensive males
Comparison
Graded lower body negative pressure protocol vs Baseline
Design
Other
Authors
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May support time-domain baroreflex assessment during orthostasis; leaves open utility for predicting tolerance in broader populations.
Absolute Event Rate: 5.44% vs 2.55%
Time domain analysis of microneurography during orthostatic stress demonstrates functional adaptation of neuronal pathways, with increased MSNA bursts and decreased stimulus/response times.
Laurin et al. (2017) studied Healthy, normotensive (n=11). Graded lower body negative pressure (LBNP) vs. Baseline was evaluated on Number of MSNA bursts per low-frequency cycle. Graded lower body negative pressure increased the number of MSNA bursts per low-frequency cycle from 2.55 ± 0.68 at baseline to 5.44 ± 1.56 at -40 mmHg.
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