Key result
In a rat model of diabetes, high plasma angiotensin II and insulin enhanced endothelin-1-induced vasoconstriction, which was blunted by chronic losartan administration.
In a diabetic rat model, high plasma insulin and angiotensin II augment endothelin-1-induced vasoconstriction via ETA receptors and ERK, an effect attenuated by the angiotensin II receptor antagonist losartan.
May support losartan investigation in diabetic vasculopathy; leaves open clinical translation pending human studies.
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Kobayashi et al. (2008) studied hyperinsulinaemic diabetes (rat model). Losartan vs. Control diabetic rats was evaluated on Endothelin-1-induced contractile responses and receptor expression. In a rat model of diabetes, high plasma angiotensin II and insulin enhanced endothelin-1-induced vasoconstriction, which was blunted by chronic losartan administration.
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