Key result
Increasing aortic stiffness was associated with decreased cardiac oxygen supply potential (change in Diastolic Pressure Time Index -0.70 mmHg s; 95% CI -0.86 to -0.54) and increased oxygen demand.
Why the study?
Is aortic stiffness associated with decreased cardiac oxygen supply potential and increased cardiac oxygen demand in older adults?
Population
2,490 older adults from the Rotterdam Study (a large population-based study)
Design
Cohort
Authors
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Supports mechanistic link between aortic stiffness and myocardial oxygen imbalance in older adults; hypothesis-generating and should not yet change practice.
Observational (n=2,490)
Is aortic stiffness associated with decreased cardiac oxygen supply potential and increased cardiac oxygen demand in older adults?
Mean Difference: -0.7 (95% CI -0.86–-0.54)
Aortic stiffness is associated with increased cardiac oxygen demand and decreased supply potential, providing a potential physiological mechanism for its link to cardiovascular morbidity and mortality.
Guelen et al. (2008) conducted an observational in Older adults (n=2,490). Aortic stiffness was evaluated on Cardiac oxygen supply potential (Diastolic Pressure Time Index) (Coefficient -0.70 mmHg s, 95% CI -0.86 to -0.54). Increasing aortic stiffness was associated with decreased cardiac oxygen supply potential (change in Diastolic Pressure Time Index -0.70 mmHg s; 95% CI -0.86 to -0.54) and increased oxygen demand.
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