What question did this study set out to answer?

To evaluate the clinical utility of arterial stiffness measurements, particularly pulse wave velocity, for cardiovascular risk stratification and therapeutic monitoring.

August 1, 2002American Journal of Hypertension

Prognostic application of arterial stiffness: task forces

Q: What does this research mean for the field?

Measurement of aortic pulse wave velocity (PWV) is a strong independent predictor of cardiovascular mortality and a valuable tool for risk stratification and monitoring therapeutic efficacy, particularly in patients with end-stage renal disease. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Why the study?

Does the measurement of arterial stiffness (such as aortic PWV) predict cardiovascular risk and mortality in high-risk populations?

Population

General population, patients with end-stage renal disease on hemodialysis, patients with essential…

Design

Review

Authors

GLG. LondonFrench Clinical Research Infrastructure Network JCJ. N. CohnUniversity of Minnesota Medical Center

Discussion

Member takes

Implication

Supports PWV assessment for CV risk stratification in ESRD and hypertension; leaves open whether stiffness reduction improves outcomes beyond BP lowering.

Key Points

To evaluate the clinical utility of arterial stiffness measurements, particularly pulse wave velocity, for cardiovascular risk stratification and therapeutic monitoring.
Synthesized epidemiological and clinical trial data evaluating arterial stiffness parameters, including aortic pulse wave velocity and carotid distensibility.
Assessed cardiovascular and all-cause mortality outcomes across cohorts of patients with end-stage renal disease on hemodialysis, essential hypertension, and individuals older than 80 years.
Aortic pulse wave velocity independently predicted cardiovascular and all-cause mortality in end-stage renal disease, essential hypertension, and older adults over 80 years.
Carotid distensibility independently predicted cardiovascular risk in both end-stage renal disease patients and renal transplant recipients.
A lack of aortic pulse wave velocity reduction despite drug-induced blood pressure lowering significantly predicted cardiovascular death in end-stage renal disease.

Structured PICO

Does the measurement of arterial stiffness (such as aortic PWV) predict cardiovascular risk and mortality in high-risk populations?

Population

General population, patients with end-stage renal disease (ESRD) on hemodialysis, patients with essential hypertension, older subjects over 80 years, and renal transplant recipients

Intervention

Measurement of arterial stiffness (aortic pulse wave velocity [PWV] and carotid distensibility)

Outcome

Cardiovascular and all-cause mortalityhard clinical

Measurement of aortic stiffness via pulse wave velocity is a valuable tool for cardiovascular risk stratification and monitoring therapeutic efficacy, particularly in ESRD and hypertensive patients.

Cite This Study

London et al. (2002) studied this question.

synapsesocial.com/papers/6a19e39e05af093a17f6b4ea https://doi.org/10.1016/s0895-7061(02)02966-7

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Implication

Supports PWV assessment for CV risk stratification in ESRD and hypertension; leaves open whether stiffness reduction improves outcomes beyond BP lowering.

Prognostic application of arterial stiffness: task forces

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Prognostic application of arterial stiffness: task forces

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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