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August 1, 1987Journal of Hypertension

Renal Haemodynamic Studies in Obesity Hypertension

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Why the study?

Does obesity alter renal and systemic haemodynamics in normotensive and hypertensive patients?

Population

Obese and lean normotensive and hypertensive patients

Comparison

Obesity vs Lean normotensive and hypertensive patients

Design

Cross-sectional

Authors

ERE REISINLouisiana State University Health Sciences Center New OrleansFMFranz G. MesserliLouisiana State UniversityHVHéctor O. VenturaHeart Failure / Cardiomyopathy

Discussion

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Implication

Obesity may drive compensatory volume expansion offsetting vasoconstriction; leaves open longitudinal cardiovascular effects in cross-sectional data.

Key Points

  • To evaluate and compare renal and systemic haemodynamics between obese and lean individuals with and without hypertension.
  • Comparative haemodynamic assessment across cohorts of obese and lean normotensive and hypertensive individuals.
  • Evaluation of systemic and renal haemodynamic parameters, including renal blood flow, blood volume, cardiac output, and vascular resistances.
  • Obese normotensive and hypertensive subjects exhibited elevated renal blood flow, total blood volume, and cardiac output, alongside decreased total peripheral and renal vascular resistances relative to lean counterparts.
  • Body weight correlated directly and significantly with total blood volume, cardiac output, and renal blood flow, but showed an inverse correlation with total peripheral resistance.

Structured PICO

Does obesity alter renal and systemic haemodynamics in normotensive and hypertensive patients?

P
Population
Obese and lean normotensive and hypertensive patients
I
Intervention
Obesity
C
Comparator
Lean normotensive and hypertensive patients
O
Outcome
Renal and systemic haemodynamics (renal blood flow, total blood volume, cardiac output, total peripheral and renal vascular resistances)surrogate

Obesity is associated with volume expansion and increased renal perfusion, which reduces renal vascular resistance and may counteract the vasoconstriction typically seen in hypertension.

Cite This Study

REISIN et al. (1987) studied this question.

synapsesocial.com/papers/6a79d72e77336a1bae02831ahttps://doi.org/10.1097/00004872-198708000-00002

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity and Essential Hypertension1981 · 207 citations
  2. 2Obesity and essential hypertension. Hemodynamics, intravascular volume, sodium excretion, and plasma renin activity1981 · 281 citations
  3. 3Hypertension in obese patients: hemodynamic and volume studies.1982 · 50 citations
  4. 4The problem of obesity and hypertension.1983 · 86 citations
  5. 5Does obesity influence early target organ damage in hypertensive patients?1993 · 84 citations