Why the study?
Does Bay K 8644 affect post-rest contraction in canine right ventricular trabecula?
Does Bay K 8644 affect post-rest contraction in canine right ventricular trabecula?
The calcium channel agonist Bay K 8644 impairs calcium release from the sarcoplasmic reticulum during rest in mammalian ventricular tissue.
Bay K 8644 may impair post-rest SR calcium release in canine trabeculae; leaves open relevance to human ventricular function.
Positive inotropic concentration of the Ca-channel agonist, Bay K 8644, depressed contraction of canine right ventricular trabecula immediately after a rest period of 8 min, without decreasing action potential plateau amplitude. In contrast, high external Ca and ouabagenin caused only a slight decrease in post-rest contraction. Bay K 8644-induced post-rest depression was inversely related to the extracellular Ca concentration. Hence it could not be due to cellular Ca overload. Since post-rest potentiation is due to increased contribution of Ca from the sarcoplasmic reticulum, these results suggest that Bay K 8644 decrease the amount of releasable Ca from this structure during rest.
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Hryshko et al. (1988) studied this question.
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