January 10, 2013Journal of Hypertension
Sex differences in cardiovascular outcomes in patients with incident hypertension
Key result
Among patients with incident hypertension, women were more likely to develop chronic kidney disease than men (9.60% vs 7.15%; HR 1.17, 95% CI 1.12-1.22) but had lower risks of death, MI, and stroke.
Why the study?
Are there sex differences in the risk of adverse cardiovascular outcomes and CKD among patients with incident hypertension?
Population
177,521 women and men with incident hypertension from 2001 to 2006 enrolled in the Cardiovascular Research…
Comparison
Female sex vs Male sex
Design
Cohort
Follow-up
median 3.2 years (interquartile range 1.6-4.8)
Authors
Discussion
Loading...
Member takes
Implication
May warrant closer CKD surveillance in women with new hypertension; leaves open need for prospective validation and targeted interventions.
Study Design
Type
Cohort (n=177,521)
Multicenter
Yes
Structured PICO
Are there sex differences in the risk of adverse cardiovascular outcomes and CKD among patients with incident hypertension?
P
Population
177,521 patients (55% women) with incident hypertension followed for a median of 3.2 years.
E
Exposure
Female sex
C
Comparator
Male sex
O
Outcome
Incident events including all-cause death; hospitalization for myocardial infarction (MI), heart failure or stroke; and the development of chronic kidney disease (CKD)hard clinical
Main Result
Hazard Ratio: 1.17 (95% CI 1.12–1.22)
Absolute Event Rate: 9.6% vs 7.15%
In patients with incident hypertension, women have a lower risk of death, MI, and stroke, but a higher risk of developing chronic kidney disease compared to men.
Cite This Study
Daugherty et al. (2013) conducted a cohort in Incident hypertension (n=177,521). Female sex vs. Male sex was evaluated on Development of chronic kidney disease (CKD) (HR 1.17, 95% CI 1.12-1.22). Among patients with incident hypertension, women were more likely to develop chronic kidney disease than men (9.60% vs 7.15%; HR 1.17, 95% CI 1.12-1.22) but had lower risks of death, MI, and stroke.