Why the study?
Diabetic cardiomyopathy is a leading cause of high morbidity and mortality in diabetic patients, and whether ginkgolide B alleviates cardiac dysfunction and its mechanism in diabetic rats required investigation.
Does ginkgolide B improve cardiac dysfunction, oxidative stress, and fibrosis in a rat model of diabetic cardiomyopathy?
Population
Rats with streptozotocin-induced diabetes
Comparison
Ginkgolide B treatment vs untreated diabetic rats
Design
Animal experimental study
Key result
Ginkgolide B significantly improved cardiac hemodynamics, including left ventricular +dP/dtmax, and attenuated myocardial fibrosis and oxidative stress in diabetic rats.
Authors
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Hypothesis-generating for diabetic cardiomyopathy; should not yet change clinical practice.
Does ginkgolide B improve cardiac dysfunction, oxidative stress, and fibrosis in a rat model of diabetic cardiomyopathy?
Absolute Event Rate: 3615.8% vs 3062.3%
p-value: p=<0.01
Ginkgolide B attenuates cardiac dysfunction, oxidative stress, and fibrosis in a rat model of diabetic cardiomyopathy, suggesting potential therapeutic value.
Jiang et al. (2020) studied Diabetic cardiomyopathy. Ginkgolide B vs. Vehicle control (diabetes model group) was evaluated on Left ventricular maximum rate of rise of pressure (+dP/dtmax) (p=<0.01). Ginkgolide B significantly improved cardiac hemodynamics, including left ventricular +dP/dtmax, and attenuated myocardial fibrosis and oxidative stress in diabetic rats.
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