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November 10, 2016Saudi Journal of Biological SciencesOpen Access

Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach

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Why the study?

Does cyanidin 3-glucoside (C3G) improve myocardial injury markers in streptozotocin-induced diabetic rats?

Population

Streptozotocin-induced diabetic rats (model for diabetic cardiomyopathy)

Comparison

Cyanidin 3-glucoside (C3G) vs Untreated diabetic rats (STZ administered)

Design

Preclinical

Authors

WLWeizhen LiShanghai Jiao Tong UniversitySCSongwen ChenShanghai Jiao Tong UniversityGZGenqing ZhouSun Yat-sen University

Discussion

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Implication

C3G shows preclinical cardioprotection in diabetic rats; leaves open translation to human diabetic cardiomyopathy.

Key Points

  • To evaluate the cardioprotective efficacy and molecular mechanisms of cyanidin 3-glucoside against diabetic cardiomyopathy in diabetic rats.
  • Diabetes was induced in rats using streptozotocin (STZ), followed by treatment with cyanidin 3-glucoside (C3G).
  • Serum lipid profiles (total triglycerides, total cholesterol) and cardiac injury marker enzymes (AST, CK, LD) were measured.
  • Inflammatory cytokine levels (TNF-alpha, IL-6) and apoptotic pathway markers (Bcl-2, caspase-3, BAX) were evaluated using immunohistochemistry and western blot analysis.
  • Marker enzymes of cardiac injury (CK, LD, and AST) were significantly elevated in STZ-induced diabetic rats (P < 0.05), but treatment with C3G significantly reduced these elevated levels (P < 0.05).
  • C3G administration led to a marked reduction in inflammatory cytokines TNF-alpha and interleukin-6 compared with the untreated diabetic group.
  • Western blot analysis demonstrated that C3G significantly increased anti-apoptotic Bcl-2 expression while downregulating pro-apoptotic markers caspase-3 and BAX.

Structured PICO

Does cyanidin 3-glucoside (C3G) improve myocardial injury markers in streptozotocin-induced diabetic rats?

P
Population
Streptozotocin-induced diabetic rats (model for diabetic cardiomyopathy)
I
Intervention
Cyanidin 3-glucoside (C3G)
C
Comparator
Untreated diabetic rats (STZ administered)
O
Outcome
Levels of myocardial injury marker enzymes (aspartate aminotransferase [AST], creatine kinase [CK], and lactate dehydrogenase [LD])surrogate

In a rat model of diabetic cardiomyopathy, cyanidin 3-glucoside (C3G) ameliorated myocardial injury, inflammation, and apoptosis, suggesting a potential protective role against cardiovascular complications in diabetes.

Cite This Study

Li et al. (2016) studied this question.

synapsesocial.com/papers/6a8239eaa480f00e4bac90a6https://doi.org/10.1016/j.sjbs.2016.11.007
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